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Vendôme is a subprefecture of the department of Loir-et-Cher, France. It is also the department's third-biggest commune with 15,856 inhabitants (2019). It is one of the main towns along the river Loir. The river divides itself at the entrance of Vendôme, intersecting it into numerous different arms. The town has a rich medieval history and many historical monuments. Vendôme is the main center of activity of the Communauté d'Agglomeration Territoires Vendômois (The Territoires Vendômois agglomeration community is a French agglomeration community, located in the department of Loir-et-Cher and in the Centre-Val de Loire region).