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Horizon 2020 (2014 - 2020)

Small Molecules to Treat Metabolic Syndrome - PREVMETSYN

Last update: Sep 7, 2020 Last update: 07 Sep, 2020

Details

Locations: Germany
Start Date: Jan 1, 2017
End Date: Mar 31, 2019
Value: € 149 948
Sectors: Health, Research Health, Research
Categories: Grants
Date posted: Sep 7, 2020

Associated funding

Associated experts

Description

Programme: H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
Topic: 
ERC-PoC-2016 - ERC-Proof of Concept-2016
Call for proposa
l: ERC-2016-PoC
Funding Scheme: ERC-POC - Proof of Concept Grant
Grant agreement ID: 727726

Objective: SMALL MOLECULES TO TREAT METABOLIC SYNDROME Metabolic Syndrome (MS) is defined as a cluster of inter-related symptoms including central obesity, insulin resistance, dyslipidemia, and hypertension that promote the development of type 2 diabetes mellitus, cardiovascular diseases and certain cancers. In this project a pharmacological strategy will be developed that could alleviate the vicious circle of hyperglycemia (elevated blood glucose) and elevated insulin observed in metabolic syndrome that accelerates the onset of type 2 diabetes. We have identified a new protein that participates in insulin-dependent increase in glucose uptake from the blood. Loss of this protein leads to reduced insulin dependent glucose uptake and a metabolic syndrome like disease in mice. In this project small molecules that modulate the function of the said protein will be developed and evaluated. New molecules that enhance glucose uptake into cells could be potentially powerful new tools to reverse insulin resistance a key pathology of metabolic syndrome that can accelerate the onset of type 2 diabetes.

Reference — Small Molecules to Treat Metabolic Syndrome - PREVMETSYN — for Germany presented by Horizon 2020 (2014 - 2020) (grants), budget is € 149 948, in Health, Research sectors. Reference — Small Molecules to Treat Metabolic Syndrome - PREVMETSYN — for Germany presented by Horizon 2020 (2014 - 2020) (grants), budget is € 149 948, in Health, Research sectors. Reference — Small Molecules to Treat Metabolic Syndrome - PREVMETSYN — for Germany presented by Horizon 2020 (2014 - 2020) (grants), budget is € 149 948, in Health, Research sectors. Reference — Small Molecules to Treat Metabolic Syndrome - PREVMETSYN — for Germany presented by Horiz...
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