Breakthrough Brain Stimulation Device for Epilepsy: BFORE

Programme(s): HORIZON.3.1 - The European Innovation Council (EIC)

Topic(s): HORIZON-EIC-2022-ACCELERATOROPEN-01 - EIC Accelerator Open

Call for proposal: HORIZON-EIC-2022-ACCELERATOR-01

Funding Scheme: EIC-ACC - EIC-ACC

Grant agreement ID: 190133715

Objective:
EASEE® stands for epicranial application of stimulation electrodes in epilepsy. It is the first minimally invasive device for focal cortical stimulation. Based on the Laplace electrode (central electrode surrounded by a ring electrode), EASEE® features 4 distinct electrodes replacing the outer ring, connected to 4 independent current sources to account for impedance and anatomical variances in the human skull. Still, the characteristic quadrupolar local electric field with high penetration depth is maintained.
The stimulation pattern is one of a kind. EASEE® is equipped for high frequency, DC-like, and low-frequency stimulation, depending on the condition to be treated. In epilepsy, intermittent high-frequency stimulation bursts throughout the day are combined with a 20min DC-like stimulation session. This first is meant to terminate upcoming seizures, the second to initiate neuromodulatory processes to down-regulate the overexcitability of the epileptic brain area.