Horizon Europe (2021 - 2027)

Automated Clinical Platform for Personalized Antibiotherapy in Critical Units Based on Surface Enhancement Raman Spectroscopy: ACU-SERS

Last update: May 23, 2024 Last update: May 23, 2024

Details

Locations:Denmark
Start Date:May 1, 2024
End Date:Apr 30, 2027
Contract value: EUR 2,499,997
Sectors:Health, Research, Science & Innovation Health, Research, Science & Innovation
Categories:Grants
Date posted:May 23, 2024

Associated funding

Associated experts

Description

Programme(s): HORIZON.3.1 - The European Innovation Council (EIC) 

Topic(s): HORIZON-EIC-2023-TRANSITIONCHALLENGES-01 - EIC Transition Challenge: Full scale Micro-Nano-Bio devices for medical and medical research applications

Call for proposal: HORIZON-EIC-2023-TRANSITION-01

Funding Scheme: HORIZON-EIC - HORIZON EIC Grants

Grant agreement ID: 101158666

Objective:

Sepsis is a leading cause of death in hospitals resulting in ~700k deaths in Europe each year. Patients urgently require critical care and are admitted to an intensive care unit (ICU), where they are treated with antibiotics. However, antibiotic dosing is inappropriate in ~50% of sepsis patients, causing poor clinical outcomes due to increased adverse events, (neuro)toxicity and contributing to antibiotic resistance. Antibiotic dosing can be significantly improved through therapeutic drug monitoring (TDM), but current workflows for drug quantification in clinics and ICU are slow, expensive, and inflexible, which have greatly limited TDM implementation. We develop ACU-SERS: a first-in-class, highly flexible, fast, and cost-effective system that fully automates the biological sample pre-treatment, analyte separation and analysis and provides a quantitative antibiotic drug level concentration in ~15 minutes. ACU-SERS' breakthrough technology combines centrifugal microfluidics with an integrated surface-enhanced Raman spectroscopy (SERS) chip to perform label-free, rapid detection and quantification in an easy-to-use benchtop device. Based on the H2020 SERSing project, this project builds on developing the Ramanbased analyser device and the optimal cartridge, as well as validating the scalability of the product and the system with clinical samples. From the commercial side, we will validate the commercial potential of our solution, found a spin-off company to commercialize the technology, and make it investment-ready. We envision that the spin-off will generate early revenues from direct sales in our initial target markets within the EU. After demonstrating market traction, we will seek to close a global distribution deal with a large diagnostics company for the TDM antibiotic market. Revenues will be reinvested to adapt ACU-SERS for TDM applications in other potential markets, such as antiepileptics, immunosuppressants and applications in pharmaceutical research.

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