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The Centers for Disease Control and Prevention (CDC) established an office in Tanzania in 2001 to support HIV/AIDS prevention and expanded through the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) in 2003. CDC works with Tanzania to strengthen tuberculosis (TB) prevention efforts for people living with HIV; enhance laboratory, surveillance, and workforce capacity to respond to disease outbreaks through the Global Health Security Agenda; and implement interventions to prevent and control malaria under the U.S. President’s Malaria Initiative.