Liposomes As Nanoreactors for the Bottom-up Assembly of Supramolecular Structures in Confined Space: LipoNanoReactors

Programme(s): HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) 

Topic(s): HORIZON-MSCA-2021-PF-01-01 - MSCA Postdoctoral Fellowships 2021

Call for proposal: HORIZON-MSCA-2021-PF-01

Funding Scheme: HORIZON-AG-UN - HORIZON Unit Grant

Grant agreement ID: 101065037

Objective:
Nanoreactors are attractive systems for emerging technologies because they allow the manipulation of matter on a molecular scale to fabricate macroscale products. Consequently, nanoreactors have been used to carry out molecular synthesis and catalysis, where such processes are controlled and stimulated by confined space. However, the current nanoreactors suffer from a lack in the flow-control of substrate that can access their interior and they have not been used to build large supramolecular structures. To overcomes these disadvantages and improve the application of nanoreactors, in this project we propose a novel design of a nanoreactor based on the combination of liposomes and molecular transporters (LipoNanoReactors). We envisage that by a controlled transport of ions (metal cations or organic anions) through phospholipid membranes, we will be able to build supramolecular structures inside liposomes, where the final structure could be modulated by the rate of ion flow and confinement effects. As a result, this strategy will allow us to control the physical and chemical properties of such structures on a nanometric scale. Further than achieving supramolecular assembly inside liposomes, the present proposal looks to facing challenges as supramolecular isomerism, crystalline phase purity, and particle size control. Accordingly, this project opens new horizons in the field of crystal engineering, solid-state chemistry, and material sciences.